Depression is a mental disorder with high prevalence and high clinical cure rate, but it also has the characteristics of low treatment rate and high recurrence rate.
The Chinese scientific research team successfully deciphered the “human body happiness code”-serotonin, which brings new hope for the treatment of mental illnesses such as depression and schizophrenia.
Media reports, shows published in a “Nature” magazine’s most detailed study , first reported nearly atomic resolution structure of three kinds of serotonin receptors,
made for the development of new safe and effective treatment of mental illness provide an important basis for drugs .
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It is reported that the research results were completed by the team of Xu Huaqiang and Jiang Yi from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences,and Zhang Yan’s team from Zhejiang University,as well as multiple research groups at home and abroad.
It revealed for the first time how phospholipids and cholesterol regulate receptor function and antidepressant. The molecular regulation mechanism of the disease drug Aripiprazole.
According to data disclosed by the World Health Organization (WHO) in 2019, there are more than 350 million people in the world, and the number of patients suffering from depression has increased by about 18% in the past decade. According to estimates, there are nearly 100 million people suffering from depression in my country, and the incidence of depression is about 3%-5%.
It is understood that serotonin receptors, also known as serotonin receptors or 5-HT receptors, are a group of G protein-coupled receptors
and ligand-gated ions that appear in the center of the central nervous system,
and around the peripheral nervous system. aisle.
In addition, serotonin is also an important neurotransmitter,
it plays a role in the brain, giving us the ability to feel happiness and happiness,
So it is also called “happy neurotransmitter.”
The serotonin system is involved in a wide range of physiological functions of the human body,
including the regulation of the brain’s memory, cognition,
emotion, learning and addiction.
Disorders of this system may cause a variety of mental illnesses,
such as depression, schizophrenia, and mania.
Depression, bipolar disorder, migraine, etc.
The physiological functions of serotonin are mediated by more than a dozen serotonin receptors, so clarifying their molecular structure and functional mechanism will bring new hope for the treatment of depression and schizophrenia and other mental diseases. .
Previously, scientists had little understanding of the fine structure of serotonin family receptors,
making the development of new targeted drugs very difficult.
Thanks to the single-particle cryo-electron microscopy technology,
the researchers analyzed for the first time the cryo-EM structure of three serotonin receptors binding different ligands.
The three structures include the structure of 5-HT1A receptor,
a target for depression and schizophrenia, the structure of 5-HT1D receptor,
Target for migraine therapy, and 5-HT1E receptor,
a potential selective therapeutic target for various mental diseases The structure of the body.
The researchers said that the serotonin receptor is a protein located on the cell membrane.
In addition to endogenous ligands and drug molecules that can regulate their functions,
lipids also play a vital role in maintaining the normal function of the receptor. effect.
The structure of these serotonin receptors analyzed this time demonstrates the molecular regulation mechanism of 5-HT1A receptors by phospholipids and cholesterol,
which will provide important information for the in-depth understanding of the serotonin system and the development of new,
safe and effective drugs for the treatment of mental diseases. basis.